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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Translational Geroscience Strategies for Delaying Multimorbidity.

Pukar Khanal1, Jagdish Chand1, Vishal S Patil1,2

  • 1Silicon Script Sciences Private Limited, Bharatpur, Ghorahi, Dang 22400, Nepal.

ACS Pharmacology & Translational Science
|April 16, 2026
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Summary
This summary is machine-generated.

Geroscience reframes aging as a modifiable factor, not inevitable. Emerging interventions target aging drivers to delay multiple age-related diseases and extend healthspan, aiming for healthier longevity.

Keywords:
agingepigeneticsmultimorbidityresiliencesenolytics

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Area of Science:

  • Gerontology and regenerative medicine, focusing on the biology of aging.

Background:

  • Global aging populations increase the burden of chronic age-related diseases.
  • Aging is increasingly viewed as a modifiable risk factor, not an inevitable decline.
  • Current medical approaches often treat individual diseases rather than aging itself.

Purpose of the Study:

  • To review advances in geroscience for modifying aging.
  • To explore interventions targeting conserved aging drivers.
  • To discuss strategies for extending healthspan and compressing morbidity.

Main Methods:

  • Review of current geroscience literature and emerging interventions.
  • Exploration of biological drivers of aging: genomic instability, epigenetic dysregulation, mitochondrial dysfunction, stem cell exhaustion.
  • Discussion of innovative strategies like senolytics and epigenetic reprogramming.

Main Results:

  • Geroscience offers potential to delay multiple age-related diseases concurrently.
  • Senolytics and epigenetic reprogramming show promise for extending healthspan.
  • Challenges include inter-species efficacy, reprogramming safety, and ethical considerations.

Conclusions:

  • A paradigm shift towards targeting aging mechanisms is needed.
  • Precision-based approaches and advanced tools (AI, organ-on-a-chip, multiomics) can redefine healthy aging.
  • Integrating mechanistic discoveries into clinical practice is crucial for resilience and vitality in aging.