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Effects of a culturally tailored intervention on medication adherence in Chinese and Vietnamese Americans with

Lin Zhu1, Wenyue Lu1, Zhiqing Elaine Liu1

  • 1Center for Asian Health, Department of Population Health Sciences, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

Frontiers in Public Health
|April 16, 2026
PubMed

Insights

A culturally appropriate intervention improved medication adherence for Chinese and Vietnamese Americans with chronic hepatitis B (CHB). Mental health support is crucial for managing CHB and preventing liver cancer in these populations.

Area of Science:

  • Hepatology and Gastroenterology
  • Public Health
  • Clinical Trials

Background:

  • Asian Americans face disproportionately high rates of chronic hepatitis B (CHB).
  • Medication adherence is key to managing CHB and preventing liver cancer.
  • Adherence rates in Chinese and Vietnamese American populations remain understudied.

Purpose of the Study:

  • To investigate the impact of a community-based, culturally appropriate intervention on HBV medication adherence.
  • To assess long-term adherence improvements in vulnerable Asian American populations.
  • To identify factors associated with medication adherence in CHB patients.

Main Methods:

  • A randomized controlled trial was conducted with 129 Chinese and Vietnamese American CHB patients.
  • Medication adherence was measured using the 8-Item Morisky Medication Adherence Scale.
  • Ordinary least squares (OLS) regression analyzed intervention effects and covariates.

Main Results:

  • The intervention significantly improved medication adherence at 12 months (coefficient=0.56, p=0.04).
  • Limited English proficiency (74.4%) and lack of health insurance (9.3%) were noted.
  • Baseline depression scores negatively correlated with adherence (coefficient=-0.10, p=0.003).

Conclusions:

  • A culturally tailored intervention effectively enhanced CHB medication adherence over 12 months.
  • Integrating mental health support is vital for improving adherence in this demographic.
  • Findings highlight the need for culturally sensitive CHB management strategies.
Abstract

Keywords:
community-based participatory researchhealth behavior changemHealthmedication adherencevirtual patient education

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