Related Experiment Video

Updated: Apr 17, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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Natural Modulators of the TP53 Pathway: Potential Herbal and Plant-Derived Agents for Cancer Therapy

Sudeshna Nandi1, Arghya Naskar2, Somanjana Khatua3

  • 1Department of Botany, Vedanta College, Kolkata, India.

Phytotherapy Research : PTR
|April 16, 2026
PubMed

Insights

Natural products can target the p53 tumor suppressor gene, which is mutated in many cancers. This review explores how these compounds modulate p53 activity for cancer treatment and prevention.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • The p53 protein, a critical tumor suppressor, is frequently mutated in human cancers.
  • p53 regulates essential cellular processes like cell cycle arrest, apoptosis, and DNA repair to maintain genomic integrity.
  • Mutations in the TP53 gene are implicated in a wide range of malignancies, including breast, lung, and colon cancers.

Purpose of the Study:

  • To review recent advances in identifying and developing natural products as anticancer agents.
  • To highlight the therapeutic potential of natural compounds in modulating the p53 signaling pathway.
  • To explore the role of natural products in cancer treatment and prevention by targeting p53.

Main Methods:

  • Literature review of scientific articles and research papers.
  • Analysis of studies focusing on natural products and their interaction with the p53 pathway.
  • Synthesis of information on compounds that modulate p53 expression or activity.

Main Results:

  • Natural products offer a promising source for novel anticancer therapeutics.
  • Several natural compounds have demonstrated the ability to target mutant p53 in cancer cells.
  • Modulating p53 expression or activity with natural products is a viable strategy for cancer intervention.

Conclusions:

  • Natural products represent a valuable resource for developing new cancer therapies.
  • Targeting the p53 pathway with natural compounds shows potential for both cancer treatment and prevention.
  • Further research into these natural products could lead to effective strategies against various cancers.
Keywords:
MDM2bioactive compoundsclinical trialsmedicinal plantsmutant p53p53 pathway

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