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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Related Experiment Video

Updated: Apr 18, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
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Interface Wettability Transition-Driven Drug Release and Dual-Phase Functionalization in Implant Abutment.

Zhongchao Wang1,2,3, Liang Shi2,3,4, MingXia Li2,3,5

  • 1Department of Periodontics & Oral Mucosal Diseases, The Affiliated Stomatological Hospital, Southwest Medical University, Luzhou, Sichuan, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|April 16, 2026
PubMed
Summary

This study created a smart coating for dental implants that prevents early bacterial contamination and later inflammation. The innovative superhydrophobic-to-wettable transition coating offers sustained drug release for improved healing.

Keywords:
anti‐foulingdrug releaseimplant abutmentsinterfacial wettabilitymicro‐environment regulation

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Area of Science:

  • Biomaterials Science
  • Dental Implantology
  • Nanotechnology

Background:

  • Dental implant abutments are susceptible to early biological contamination and late-stage inflammation.
  • Existing treatments often fail to address both challenges effectively, leading to complications like peri-implantitis.

Purpose of the Study:

  • To develop a smart, dual-action drug-release coating for dental implant abutments.
  • To utilize a superhydrophobic-to-wettable transition mechanism for sequential surface functionality.
  • To mitigate early-stage bacterial adhesion and late-stage inflammatory responses.

Main Methods:

  • Constructed a coating using hydrophobic micelles self-assembled on mesoporous silica nanoparticles loaded with berberine.
  • Engineered the coating to exhibit a superhydrophobic state initially, transitioning to a wettable state upon protein deposition.
  • Evaluated the coating's performance through in vitro and in vivo experiments.

Main Results:

  • The superhydrophobic surface effectively resisted initial protein and bacterial adhesion.
  • Protein deposition triggered a transition to a hydrophilic state, initiating a sigmoidal drug release profile.
  • In vivo studies showed a 22.5-fold enhancement in antibacterial efficacy, reduced inflammation, and promoted soft tissue closure.

Conclusions:

  • The developed smart coating provides sequential "early-antifouling-enabled late active regulation" for dental implant abutments.
  • This strategy offers a promising solution for preventing peri-implant inflammation and soft tissue dehiscence.
  • The coating's tunable drug release mechanism addresses the dual challenges of dental implant abutments.