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Updated: Apr 18, 2026

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
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Hypertensive Anterior Uveitis Following Intravitreal Faricimab.

Ellen Y Rhodes1, Julia L Xia1, Talisa E de Carlo Forest1

  • 1Department of Ophthalmology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Ocular Immunology and Inflammation
|April 16, 2026
PubMed
Summary

Three patients developed hypertensive anterior uveitis after intravitreal faricimab injections. This rare complication, negative for infection, resolved with corticosteroid treatment and drug discontinuation.

Keywords:
Anti-VEGFfaricimabhypertensive uveitis, Vabysmo

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Uveitis

Background:

  • Intravitreal faricimab is used for diabetic macular edema (DME) and neovascular age-related macular degeneration (nAMD).
  • Ocular inflammation can be a complication of intravitreal injections.

Purpose of the Study:

  • To describe findings in three cases of hypertensive anterior uveitis following intravitreal faricimab.
  • To investigate culture and PCR-negative uveitis post-faricimab treatment.

Main Methods:

  • Case series of three patients treated with intravitreal faricimab.
  • Data included visual acuity, intraocular pressure (IOP), slit lamp examination, and anterior chamber/vitreous tap for PCR.
  • Patients received topical/local corticosteroids and IOP-lowering therapy as needed.

Main Results:

  • Three patients developed hypertensive anterior uveitis 2-5 weeks post-injection.
  • Symptoms included ocular pain, redness, elevated IOP (22-52 mmHg), and anterior chamber inflammation with keratic precipitates.
  • Infectious workups (PCR) were negative; inflammation resolved within 3 months after discontinuing faricimab.

Conclusions:

  • Hypertensive anterior uveitis is a potential rare complication of intravitreal faricimab.
  • Consider this diagnosis in patients with new ocular inflammation or IOP elevation during faricimab treatment.
  • Discontinuation of faricimab and corticosteroid treatment effectively resolved inflammation.