Related Experiment Video
Updated: Apr 18, 2026
Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection
Published on: May 13, 2019
CrMo6 based POMOF-nanozyme for colorimetric and electrochemical dual-mode precise sensing dopamine
Yunjie Li1, Yawen Guan1, Xinyu Han1
1Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Key Laboratory for Photonic and Electronic Bandgap Materials, Ministry of Education, College of Chemistry and Chemical Engineering, Key Laboratory of Molecular Cytogenetics and Genetic Breeding, College of Life Science and Technology, Harbin Normal University, Harbin 150025, Heilongjiang Province, China.
Abstract:
As a crucial biomarker, dopamine (DA) serves in diagnosis and treatment of severe neurodegenerative and psychiatric disorders. The precise, efficient, and intuitive sensing of DA is crucial to disease diagnostics, but remains a great challenge. Herein, a dual-mode colorimetric and electrochemical sensing platform based on a peroxidase (POD)-like nanoreactor CuBTC@CrMo6 was constructed, achieving portable and accurate cascade sensing of H2O2 and DA via colorimetric-mode, with a limit of detection (LOD) of 10.13 μM and 0.51 μM, and the electrochemical-mode implemented a broader detection range of 0.1-150 μM with an ultra-low LOD of 31.03 nM for DA. Satisfactory recoveries in serum and milk were attained at 98.6%-106.2%, with RSD less than 4%. Mechanistic studies manifested critical role of POD-like activity in dual-mode strategies, accomplishing the efficient self-correcting detection. The POMOF-based nanoreactors provide robust, multimodal biosensors for biomarker detection, which offer significant advancements in both detection of spiked samples and food safety.
