Periocular Rejuvenation with PRF Gel

Age-related changes in the periorbital region contribute to tear trough deepening and infraorbital hollowing, which create a fatigued appearance.

Platelet concentrates have been used for many years for their regenerative capabilities. Platelet-rich fibrin (PRF) Gel has recently been introduced as a natural alternative to hyaluronic acid (HA) fillers for periorbital rejuvenation.

The main cause for periorbital hollowness is volume loss in the fat pads, most specifically the sub-orbicularis oculi fat (SOOF).

PRF Gel is well-suited for patients seeking a conservative approach, especially those with prior HA-related complications or compromised lymphatic drainage.

PRF Gel is created by combining denatured albumin (2,600 rpm, 7 minutes) with liquid PRF (1,100 rpm, 5 minutes) in a 3.5:1.5 cc ratio to form an injectable gel.

Treatment requires minimal downtime and fewer restrictions compared to HA fillers.

Prospective observations show progressive volume improvement with repeated treatments. Refinement of centrifugation and protocols may further enhance clinical outcomes.

PRF Gel offers a new and autologous treatment to patients who are seeking a more conservative and natural approach to under-eye rejuvenation.