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Periodontitis Is Associated With Serum Prostate Specific Antigen Concentrations in Chinese Male
Yifei Long1, Qi Liu1, Pengfei Shen2
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Oral Diseases
|April 17, 2026
Summary
Severe periodontitis is linked to higher prostate-specific antigen (PSA) levels in Chinese men aged 41-80. This finding may inform early PSA screening for periodontitis patients.
Area of Science:
- Oral health research
- Urology
- Biomarker analysis
Background:
- Periodontitis is a common oral condition.
- Prostate-specific antigen (PSA) is a key biomarker for prostate health.
- The relationship between periodontitis and PSA requires further investigation.
Purpose of the Study:
- To investigate the association between periodontitis and serum PSA levels.
- To explore the potential for early PSA screening in periodontitis patients.
Main Methods:
- 1409 participants underwent periodontal examinations and PSA level measurements.
- Participants were categorized into non-periodontitis, mild, moderate, and severe periodontitis groups.
- Logistic regression analysis was employed to determine associations.
Main Results:
- Severe periodontitis was associated with significantly higher PSA levels compared to non-periodontitis.
- No significant association was observed in participants aged 20-40.
- A significant association between severe periodontitis and elevated PSA was found in patients aged 41-80.
Conclusions:
- Serum PSA levels are significantly higher in Chinese men with severe periodontitis.
- Severe periodontitis is a significant factor associated with elevated PSA in older men (41-80).
