Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bone marrow immune cells respond to fluctuating nutritional stress to constrain weight regain.

Cell metabolism·2026
Same author

An efficient method for tissue-specific protoplast isolation suitable for single-cell RNA sequencing and transient gene expression analysis in saffron (Crocus sativus L.).

BMC biotechnology·2026
Same author

Correction: One-step and two-step qPCR assays for CAPRV2023: development and application in full-cycle epidemiological surveillance of golden pompano.

Frontiers in veterinary science·2026
Same author

Evaluation of the immunological efficacy of EsxA subunit vaccine and DNA vaccine against Streptococcus iniae in golden pompano (Trachinotus anak).

Fish & shellfish immunology·2026
Same author

Smart Microneedles Regulate Reactive Oxygen Species and Deliver Matrix Metalloproteinases for Pathological Scar Treatment.

ACS nano·2026
Same author

Systemic application of IL-33 for cancer immunoprevention and immunotherapy.

Molecular therapy : the journal of the American Society of Gene Therapy·2026

Related Experiment Video

Updated: Apr 18, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

69.3K

Macrophage polarization-regulating hydrogels for bone regeneration.

Tianyu Cao1,2, Kaihua Li1,2, Wei Ji2

  • 1Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215000, China. sunheng@suda.edu.cn.

Biomaterials Science
|April 17, 2026
PubMed
Summary

Hydrogels can guide macrophage polarization for bone repair by mimicking natural healing. These advanced materials support bone regeneration in various defects by controlling immune cell responses.

More Related Videos

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

3.4K
Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
08:37

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces

Published on: December 6, 2024

2.1K

Related Experiment Videos

Last Updated: Apr 18, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

69.3K
Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

3.4K
Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces
08:37

Polarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces

Published on: December 6, 2024

2.1K

Area of Science:

  • Biomaterials Science
  • Immunology
  • Regenerative Medicine

Background:

  • Bone regeneration is a complex process involving osteogenic cells and the immune system, particularly macrophages.
  • Macrophage polarization is crucial for bone healing, and immunomodulatory hydrogels offer potential therapeutic strategies.
  • Designing effective hydrogels requires addressing bone-specific needs like mechanical support and synchronized biodegradation.

Purpose of the Study:

  • To systematically review advanced hydrogel systems designed to direct macrophage polarization for enhanced bone repair.
  • To highlight material design principles that govern macrophage phenotypic switching and promote osteogenesis.
  • To evaluate the therapeutic outcomes of these hydrogels in various bone defect models.

Main Methods:

  • Review of literature on hydrogel-based immunomodulatory strategies for bone regeneration.
  • Analysis of material design principles (polymer selection, crosslinking, functionalization) influencing macrophage polarization.
  • Evaluation of hydrogel efficacy in promoting macrophage-osteoblast crosstalk and bone healing.

Main Results:

  • Hydrogels can be engineered to modulate macrophage phenotypes, promoting a pro-osteogenic microenvironment via secreted factors (e.g., BMP-2, TGF-β, VEGF).
  • These strategies show therapeutic potential in critical-sized defects and pathological conditions like infected, osteoporotic, and diabetic bone defects.
  • The principles are applicable to cartilage and tendon repair, demonstrating broader relevance.

Conclusions:

  • Advanced hydrogels offer a promising framework for harnessing macrophage plasticity to improve bone regeneration.
  • Tailored immunomodulatory hydrogels can overcome specific immunopathological barriers in diverse bone defect scenarios.
  • Integrating material science and immunology is key to developing next-generation tissue engineering therapies.