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Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
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SYSTEMIC HODGKIN LYMPHOMA WITH PRESUMED INTRAOCULAR INVOLVEMENT
Victoria A Marks1, Vijitha S Vempuluru, Carol L Shields
1Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Retinal Cases & Brief Reports
|April 17, 2026
Summary
Systemic Hodgkin lymphoma rarely affects the eye. This case shows intraocular involvement, including vitreous cells and choroidal infiltrates, that resolved with standard chemotherapy.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Hodgkin lymphoma is a malignancy of the lymphatic system.
- Intraocular involvement in Hodgkin lymphoma is rare.
- Ocular manifestations can significantly impact vision.
Purpose of the Study:
- To report a rare case of systemic Hodgkin lymphoma with presumed intraocular involvement.
- To describe the clinical presentation and diagnostic findings.
- To demonstrate the response to systemic chemotherapy.
Main Methods:
- Observational case report.
- Clinical examination including funduscopy, ultrasonography, and optical coherence tomography.
- Review of patient's systemic chemotherapy regimen.
Main Results:
- A 32-year-old woman with Stage II Hodgkin lymphoma presented with photopsia and decreased vision.
- Fundus examination revealed vitreous cells and numerous choroidal infiltrates.
- Imaging confirmed vitreoretinal and choroidal thickening; lesions resolved after chemotherapy.
Conclusions:
- This case highlights a rare presentation of Hodgkin lymphoma involving the vitreoretinal and choroidal tissues.
- Systemic chemotherapy was effective in resolving the intraocular manifestations.
- Early recognition and treatment are crucial for managing ocular complications of lymphoma.
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