MULTIMODAL IMAGING OF DIDANOSINE-RELATED RETINOPATHY

The purpose of this study was to describe multimodal imaging findings in a rare case of didanosine-related retinopathy.

This is a case report.

A 55-year-old male patient presenting peripheral visual loss and nyctalopia for the past 8 years in both eyes. He had a medical history of HIV and use of didanosine for almost 10 years. Fundus examination, autofluorescence, and optical coherence tomography showed bilateral symmetrical peripheral chorioretinal atrophy, sparing the posterior pole. Genetic testing was performed to exclude inherited retinopathies.

Didanosine-related chorioretinal toxicity is a rare disease, with few reports in the literature. Multimodal imaging and genetic testing were essential for precise diagnosis. The limitation of this report includes the late presentation of the patient to our clinic, making the evaluation difficult to determine early signs of toxicity and to determine the precise length of didanosine treatment and whether the degeneration progressed shortly after cessation of the medication.