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Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Post-traumatic Stress Disorder

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Psychological and Sociocultural Causes of Schizophrenia

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Related Experiment Video

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A New Method for Inducing a Depression-Like Behavior in Rats
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Loneliness and Suicide Risk in U.S. Veterans: A Scoping Review.

Richard A N Glisker1,2, Madison Strouse1, Emilia Fonseca1

  • 1VISN 2 Mental Illness Research, Education Clinical Center (MIRECC), James J. Peters VA Medical Center, Bronx, NY 10468, United States.

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PubMed
Summary
This summary is machine-generated.

Loneliness significantly predicts suicide risk in U.S. veterans, but research is limited. Future studies need diverse methods and populations to better understand this critical connection.

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Area of Science:

  • Psychiatry
  • Psychology
  • Public Health

Background:

  • U.S. military veterans exhibit elevated suicide risk compared to the general population.
  • Loneliness is a known risk factor for suicide in civilians, yet its specific role in veterans requires comprehensive examination.
  • Identifying risk factors and intervention targets for veteran suicide is a critical public health priority.

Purpose of the Study:

  • To conduct a scoping review of existing research on loneliness and suicide risk among U.S. military veterans.
  • To summarize methodologies and findings concerning the relationship between loneliness and suicide risk in this population.
  • To highlight psychiatric and psychological correlates and potential mediators of this association.

Main Methods:

  • A systematic search of multiple academic databases (PubMed, PsycINFO, Google Scholar, CINAHL, Scopus, PTSDpubs) was performed.
  • Empirical studies measuring both loneliness and suicide risk in U.S. veterans were included.
  • Both quantitative (self-report, medical records) and qualitative (crisis line calls) data sources were considered.

Main Results:

  • Ten out of twenty included studies identified loneliness as a significant predictor of suicide risk in veterans.
  • The majority of studies utilized self-report measures for both loneliness and suicide risk.
  • Samples were predominantly male and older veterans, potentially limiting the generalizability of findings.

Conclusions:

  • A significant association exists between loneliness and suicide risk in U.S. veterans.
  • Current research is constrained by reliance on retrospective self-report data, which are susceptible to recall bias.
  • Future research should employ diverse methodologies and recruit younger, more diverse veteran samples to enhance understanding and generalizability.