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Updated: Apr 19, 2026

Mechano-Node-Pore Sensing: A Rapid, Label-Free Platform for Multi-Parameter Single-Cell Viscoelastic Measurements

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TPP-Fabricated All-Fiber Nanoforce Sensor with Deep Learning Analysis Enables Ultrasensitive Cancer Cell

Jianchen Xie^1,2, Shibang Li^1,2, Jingjing Li^1,2

¹State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China.

Analytical Chemistry

|April 17, 2026

Summary

This summary is machine-generated.

Researchers developed an all-fiber nanoforce sensor (AFNS) for ultrasensitive mechanical measurements. This compact, cost-effective device accurately quantifies cellular mechanics, advancing cancer research.

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Published on: December 20, 2021

Area of Science:

Biophysics
Materials Science
Optical Engineering

Background:

Cellular mechanics are crucial for understanding cancer progression.
Conventional nanoforce measurement platforms face limitations in cost, size, and electromagnetic interference.

Purpose of the Study:

To develop a compact, robust, and ultrasensitive all-fiber nanoforce sensor (AFNS).
To enable routine, high-precision micro/nano-force characterization and cellular mechanics assays.

Main Methods:

Integration of a two-photon-polymerized (TPP) microcantilever onto a multimode fiber end facet.
Utilizing finite-element analysis for microcantilever design and optimization.
Decoding force-dependent multimode specklegrams with an EfficientNet-based regression model.

Main Results:

Achieved highly accurate force readout (R² = 0.9999) with a mean absolute error <0.2%.
Demonstrated a force resolution of 0.41 nN and excellent repeatability over 100 loading cycles.
Validated sensor performance by measuring Young's modulus and phenotyping cancer cells, showing agreement with atomic force microscopy.

Conclusions:

The AFNS offers a scalable, low-cost, and compact solution for ultrasensitive force measurements.
This technology provides a valuable tool for quantitative cellular mechanics and cancer research.
The all-fiber configuration overcomes limitations of conventional nanoforce sensing platforms.