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When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
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The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
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Updated: Apr 19, 2026

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
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Toward a fully distributed inhibitory control system: converging evidence across modalities.

Jung Uk Kang1

  • 1Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd. Unit #730 Houston, TX 77030-4009, United States.

Cerebral Cortex (New York, N.Y. : 1991)
|April 17, 2026
PubMed
Summary

Inhibitory control involves distributed brain networks, not just one region. New research highlights the anterior insula as a key coordinating hub in these complex neural interactions.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • Inhibitory control is traditionally linked to the right inferior frontal cortex.
  • Emerging evidence suggests distributed cortical networks play a crucial role.
Keywords:
EEGfrontal cortexfunctional connectivityinhibitory controlinsula

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