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Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
Published on: January 9, 2015
Higher order dimensions in the DSM/ICD obsessive-compulsive and related disorders
Ivar Snorrason1, Christopher C Conway2, Valerie S Swisher3
1Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, United States of America.
Obsessive-compulsive and related disorders (OCRDs) may be best understood through two distinct dimensions: compulsivity and grooming. These dimensions show varying associations with other psychopathological spectra, informing future research on their placement in broader mental health models.
Area of Science:
- Psychiatry
- Psychopathology
- Factor Analysis
Background:
- Hierarchical dimensional models of psychopathology often exclude obsessive-compulsive spectrum disorders due to insufficient data.
- This study investigates the higher-order structure of obsessive-compulsive and related disorders (OCRDs) within the DSM/ICD framework.
Purpose of the Study:
- To determine the optimal structural model for OCRDs.
- To explore the associations between OCRD dimensions and indicators from internalizing, externalizing, and thought disorder spectra.
Main Methods:
- Confirmatory factor analyses were conducted on data from community (N=1110) and clinical (N=690) samples.
- Structural regression models examined associations between OCRD dimensions and other psychopathological spectra.
Main Results:
- A two-factor model, comprising grooming (hair pulling, skin picking, nail biting/picking) and compulsivity (OCD, hoarding, body dysmorphic, olfactory reference, illness anxiety disorders), provided the best fit.
- The compulsivity factor, but not the grooming factor, demonstrated robust associations with internalizing and thought disorder spectra.
- Both factors showed weak and inconsistent associations with alcohol and substance use.
Conclusions:
- The findings support a model of OCRDs characterized by separable compulsivity and grooming dimensions.
- Further research is required to elucidate the scope of these dimensions and their integration into the broader meta-structure of psychopathology.
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