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Published on: October 2, 2016
Dimeric 2-(2-phenethyl)chromones from agarwood of Aquilaria malaccensis
Wei Li1, Xian-Yun Yan2, Hao Wang3
1Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China; International Joint Research Center of Agarwood, National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
Abstract:
Nine undescribed 2-(2-phenethyl)chromone dimers (1-6, 8-10) together with a known one (7) were isolated from the agarwood of Aquilaria malaccensis in this study. All these compounds were purified by various column chromatographic techniques, and their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS, as well as ECD calculation, and comparison with literature data. Additionally, compounds 1-10 were evaluated for their inhibition effects on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells. Compounds 1, 2, 4, 6-8 and 10 exhibited anti-inflammatory activity against NO production in RAW264.7 cells with IC50 values ranging from 6.86 ± 0.44 to 25.72 ± 3.37 μM.
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