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Targeting the liver for longevity.

Jing Yu1, Bingbing Fan1, Xiaoyan Gao1

  • 1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

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|April 17, 2026
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Summary
This summary is machine-generated.

Liver aging increases susceptibility to injury and accelerates systemic aging. Targeting liver pathways may promote longevity and treat age-related diseases by modulating the liver aging process.

Keywords:
Age-related diseasesAgeingLiverLongevity interventions

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Area of Science:

  • Gerontology
  • Hepatology
  • Molecular Biology

Background:

  • The liver is crucial for homeostasis, regulating metabolism, biosynthesis, and detoxification.
  • Liver aging compromises its function, increasing susceptibility to injury and exacerbating systemic aging.
  • Liver aging accelerates age-related diseases and interacts with other organs to promote systemic decline.

Purpose of the Study:

  • To review the impact of longevity interventions on liver aging.
  • To elucidate the mechanisms underlying these interventions.
  • To explore liver-targeted strategies for delaying aging and managing age-related diseases.

Main Methods:

  • Systematic review of existing literature on longevity interventions and liver aging.
  • Analysis of studies focusing on liver-specific pathways and their role in aging.
  • Synthesis of evidence on the effects of interventions on liver function and systemic aging.

Main Results:

  • Specific longevity interventions demonstrate effects on the liver aging process.
  • Mechanisms involve modulation of metabolic, inflammatory, and cellular stress pathways within the liver.
  • Targeting the liver shows potential for broader systemic anti-aging effects.

Conclusions:

  • The liver plays a pivotal role in systemic aging and age-related disease.
  • Liver-targeted longevity interventions offer a promising therapeutic avenue.
  • Further research into these strategies could lead to novel treatments for age-related conditions.