Related Experiment Video
Updated: Apr 19, 2026

Author Spotlight: Evaluating Therapeutic Strategies to Enhance Liver Regeneration
Published on: May 24, 2024
Targeting the liver for longevity
Jing Yu1, Bingbing Fan1, Xiaoyan Gao1
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Abstract:
The liver performs a wide range of physiological functions, including lipid/glucose metabolism, energy storage, immune regulation, molecular biosynthesis, and the clearance of xenobiotics, all of which are essential for maintaining systemic homeostasis. Liver ageing increases its susceptibility to acute stress and injury, which in turn enhances the body's sensitivity to ageing-related responses. These processes interact with other organs, accelerating systemic ageing and the pathogenesis of age-related diseases. Growing evidence indicates that targeting liver-specific pathways can promote longevity. This review summarizes the effects of longevity interventions on the liver ageing process and their underlying mechanisms, and offers perspectives on liver-targeted longevity strategies for delaying ageing and treating age-related diseases.
Related Concept Videos
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

