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Updated: Apr 20, 2026
Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Effect of triglyceride levels on bone marrow-derived dendritic cells in sepsis
Min Zhang1, Yaolu Zhang1, Fangfang Wu1
1Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Wenzhou Key Laboratory of emergency and disaster medicine, Wenzhou 325000, China.
Abstract:
The potential role of diacylglycerol acyltransferase 1(DGAT1) in regulating dendritic cell (DC) function and apoptosis in sepsis and its associated mechanisms is still unknown. Levels of very low-density lipoproteins (VLDLs), which transport endogenous triglycerides, are elevated in sepsis, leading to hypertriglyceridemia. Triacylglyceride (triacylglycerol, TAG) is the main energy storage material in life. DGAT 1 is a key enzyme in triglyceride synthesis, responsible for TAG synthesis during fat absorption and storage. This study explored the effect of the regulation of DGAT 1 expression on the immune function of dendritic cells in sepsis and associated mechanisms. Downregulation of DGAT 1 expression improved the function and apoptosis of bone marrow-derived dendritic cells in sepsis and may have activated pathway signaling proteins (JAK 2 and STAT 3) to alleviate oxidative stress and inflammation. These suggest that DGAT 1 may have a role in improving immune function in sepsis.
