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Stereotactic Radiosurgery for Gynecologic Cancer

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Published on: April 17, 2012

Domain-Specific Cognition-Sparing Stereotactic Radiosurgery: A Novel Planning Approach for Functional Preservation.

Brianna Hostler¹, Roshan Karunamuni¹, Marine Lebon²

¹Radiation Medicine and Applied Sciences, University of California San Diego School of Medicine, La Jolla, California.

International Journal of Radiation Oncology, Biology, Physics

|April 18, 2026

Summary

This summary is machine-generated.

A new stereotactic radiosurgery (SRS) planning method spares cognition by limiting radiation dose to the cognitive connectome. This approach is feasible for various brain conditions, offering a patient-centered way to preserve memory and other cognitive functions.

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Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy

Published on: October 18, 2011

Area of Science:

Neurosurgery and Radiation Oncology
Neuroscience and Cognitive Science

Background:

Stereotactic radiosurgery (SRS) is a key treatment for intracranial lesions.
Protecting cognitive function after SRS is a growing clinical concern.
The cognitive connectome, encompassing white matter tracts and hippocampi, is crucial for cognitive domains.

Purpose of the Study:

Introduce a novel cognition-sparing SRS planning framework.
Quantify the framework's ability to limit radiation dose to the cognitive connectome.
Demonstrate preferential sparing of memory, language, executive function, attention, and fine motor control.

Main Methods:

Selected three SRS cases with diverse intracranial pathologies and competing domain priorities.
Utilized automated segmentation (AtlasTrack, FreeSurfer/FastSurfer) for the cognitive connectome.
Generated standard, domain-optimized, and composite plans using non-coplanar VMAT, comparing dose metrics.

Main Results:

Domain-optimized plans successfully reduced radiation dose to prioritized cognitive structures.
An all-domains composite plan achieved balanced dose reductions across eloquent structures.
Substantial mean dose reductions were achieved even when lesions were near critical structures, maintaining target coverage.

Conclusions:

Cognition-sparing SRS is feasible, allowing for tunable dose reduction to the cognitive connectome.
This approach supports patient-centered care by incorporating cognitive priorities.
The technique is readily translatable using standard imaging and automated segmentation, with resources available online.