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Updated: Apr 21, 2026

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Cardiovascular MR in Cardiac Amyloidosis: Part II-Clinical Applications in Diagnosis, Prognosis, and Treatment
Chi Yang Chen1, Jose Alvarez-Cardona1, Ana Barac2
1Leon H. Charney Division of Cardiology, NYU Langone Cardiology Associates - 5th Floor, 530 1st Avenue, HCC 5th Floor, New York, NY 10016, USA.
Abstract:
Although adoption of noninvasive cardiac scintigraphy has transformed the diagnosis of transthyretin cardiac amyloidosis, significant challenges remain, particularly in indeterminate scintigraphy findings, light chain amyloidosis, and rare amyloid subtypes. Part I reviewed the technical foundations and key endpoints of cardiac magnetic resonance (CMR). In this Part II, we review evidence supporting the role of CMR in diagnosis, including differentiation from other causes of left ventricular wall thickening, and subtyping, particularly in early disease. We also summarize the prognostic value of CMR-derived measures. Lastly, we discuss the emerging role of serial CMR in monitoring treatment response in light chain cardiac amyloidosis.
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