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Updated: Jun 30, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

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Published on: July 22, 2020

Deciphering the Molecular Interactions of Tuberculosis and Colorectal Cancer: A Network and RNA-Seq Data Analysis

Rongrong Yu¹, Ahmad Hasan², Muhammad Ibrahim²

¹College of Education, Zhejiang University of Technology, Hangzhou, 310032, China.

Anti-Cancer Agents in Medicinal Chemistry

|April 20, 2026

Summary

This study identified six key genes, including CXCL5 and SPP1, commonly upregulated in both tuberculosis (TB) and colorectal cancer (CRC). These genes may offer new therapeutic targets for treating both diseases.

Keywords:

Tuberculosis biomarkers colorectal cancer drug targets gene expression profiling immune response.molecular interaction transcriptomics

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Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

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Published on: October 3, 2025

Area of Science:

Oncology
Infectious Diseases
Bioinformatics
Genomics

Background:

A link exists between tuberculosis (TB) and an increased risk of colorectal cancer (CRC).
Transcriptomic data analysis can reveal shared molecular mechanisms and therapeutic targets for co-occurring diseases.

Purpose of the Study:

To identify common therapeutic targets for colorectal cancer (CRC) and tuberculosis (TB) by analyzing transcriptomic data.
To explore the roles of microRNAs (miRNAs) and transcription factors (TFs) in regulating shared genes between CRC and TB.

Main Methods:

Utilized Gene Expression Omnibus datasets (GSE11199 for TB, GSE33113 for CRC).
Employed R language for identifying commonly upregulated genes.
Constructed and visualized a protein-protein interaction network using Cytoscape, Cytohubba, and MCODE.

Main Results:

Identified 40 commonly upregulated genes between TB and CRC.
Pinpointed six key hub genes: CXCL5, MMP3, MMP1, CXCL8, CXCL11, and SPP1.
Associated 58 miRNAs and 28 TFs with these hub genes, highlighting regulatory networks.

Conclusions:

CXCL5, CXCL8, CXCL11, and SPP1 are crucial genes in the tumor immune microenvironment, potentially regulating CRC and TB progression.
These identified genes and their regulatory networks (miRNAs, TFs) present promising targets for developing novel therapeutic strategies.
The findings support the development of targeted therapies for patients with both CRC and TB, advancing clinical applications.