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Distinct Neonatal Brain Anatomy Is Associated With Cross-Disorder Genetic Risk for Psychiatric Disorders

Xixi Dang1,2, Ruiqi Su3, Dan Wu3,4

  • 1Department of Psychology, Hangzhou Normal University, Hangzhou, China.

Human Brain Mapping
|April 20, 2026
PubMed
Summary

Shared genetic risk for psychiatric disorders is linked to brain development. Cross-disorder polygenic risk scores (PRS) in neonates show broader associations with brain anatomy, indicating early neurodevelopmental vulnerability.

Keywords:
brain structurecross‐disorder factorneonatal brainneurodevelopmentpolygenic risk score

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