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Advancing Infant Nutrition: Strategies for Humanizing Infant Formula through Milk Fat Globule Membrane Enrichment
Jiayi Zhao1,2, Xuemin Wang3,4, Sufang Duan3,4
1Food College, Northeast Agricultural University, No.600 Changjiang Street, Xiangfang Dist, Harbin 150030, China.
Journal of Agricultural and Food Chemistry
|April 20, 2026
Summary
Milk fat globule membrane (MFGM) is crucial for infant development, offering nutrients and regulating metabolism. Research explores MFGM
Area of Science:
- Nutritional Science
- Biochemistry
- Pediatrics
Background:
- Milk fat globule membrane (MFGM) is a vital component of breast milk, essential for infant growth.
- MFGM provides critical nutrients and influences metabolic pathways.
- Understanding MFGM's role is key for infant nutrition and formula development.
Purpose of the Study:
- To review the structure, function, and physiological roles of MFGM.
- To summarize MFGM's impact on infant lipid metabolism, neurodevelopment, immunity, and gut health.
- To present current MFGM preparation methods and their application in infant formula.
Main Methods:
- Literature review of MFGM secretory pathways, structure, and functions.
- Synthesis of research on MFGM's physiological effects.
- Analysis of MFGM extraction techniques and infant formula applications.
Main Results:
- MFGM plays a significant role in infant lipid metabolism, brain development, immune function, and intestinal health.
- Various methods exist for MFGM preparation, with ongoing advancements for infant formula.
- MFGM incorporation into formula can mimic breast milk's benefits.
Conclusions:
- MFGM is integral to infant development, impacting multiple physiological systems.
- Further research into MFGM preparation and clinical validation is needed for optimized infant formulas.
- MFGM-based infant formulas offer potential to better support infant growth and development.
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