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Solvent-dependent Mn doping: profound effects on microstructure and enhanced photothermal/photodynamic performance in
Xuejiao Li1,2, Yuxiao Wang2, Haiyang Fu2
1Key Laboratory of Superlight Materials and Surface Technology, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, PR China. yangpiaoping@heu.edu.cn.
Researchers developed novel manganese-doped tungsten oxide nanomaterials for enhanced photothermal (PTT) and photodynamic (PDT) cancer therapy. These agents utilize near-infrared light and tumor microenvironment conditions for a self-amplifying therapeutic effect.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Traditional cancer therapies face limitations including light penetration depth and tumor microenvironment (TME) challenges like hypoxia and high hydrogen peroxide (H2O2) levels.
- Developing single-wavelength activatable agents for combined photothermal therapy (PTT) and photodynamic therapy (PDT) is crucial for improved efficacy.
Purpose of the Study:
- To synthesize and characterize manganese (Mn)-doped tungsten oxide (W18O49) nanomaterials for combined PTT and PDT.
- To investigate the influence of solvent type and Mn doping concentration on material properties and phototherapeutic performance.
- To evaluate the synergistic PTT/PDT effects and TME responsiveness of the synthesized materials.
Main Methods:
- One-step solvothermal synthesis of Mn-doped W18O49 nanomaterials using n-propanol and isopropanol.
- Systematic variation of Mn doping levels and solvent conditions.
- Characterization of crystal structure, morphology, and optical properties.
- In vitro evaluation of photothermal conversion, singlet oxygen generation, H2O2 catalytic activity, and cancer cell inhibition.
Main Results:
- Solvent type and Mn doping concentration significantly influenced the microstructure and photo-conversion efficiency of W18O49 nanomaterials.
- The synthesized materials exhibited simultaneous hyperthermia and singlet oxygen (1O2) generation under single-wavelength near-infrared (NIR) irradiation.
- Mn-doped W18O49 catalyzed H2O2 to O2 in the TME, amplifying 1O2 production and enhancing the combined PTT/PDT effect.
- Significant inhibition of cancer cell proliferation was observed in vitro.
Conclusions:
- Solvent-dependent Mn doping offers a strategy to tune the properties of W18O49 for advanced phototherapeutic agents.
- The developed nanomaterials demonstrate potential as TME-responsive agents for synergistic PTT/PDT activated by single NIR light.
- This approach provides a novel pathway for overcoming limitations in current cancer treatment modalities.
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