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Updated: Apr 21, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
Investigating the Application of Stem Cell Therapy for Regenerating Dentin in Patients with Traumatic Dental
Shilpa Shetty1, Khushboo Changani2, Anjum Patan3
1Department of Conservative Dentistry and Endodontics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra, India.
Background:
Traumatic dental injuries (TDIs) often compromise the dentin-pulp complex, necessitating innovative therapeutic approaches. Stem cell therapy has emerged as a promising solution for regenerative endodontics.
Objective:
This research investigates the application of stem cell therapy in regenerating dentin for patients with TDIs by using a retrospective analysis of clinical outcomes.
Methods:
A retrospective data analysis was performed on 120 cases involving TDIs treated with stem cell-based interventions. Key parameters included patient demographics, clinical outcomes, and histological findings. Statistical significance was assessed using a P value of <0.05.
Results:
Significant improvement in dentin regeneration was observed in 85% of cases treated with stem cell therapy. Histological findings confirmed the formation of tubular dentin in 75% of cases. Younger patients exhibited superior outcomes compared to older cohorts.
Conclusion:
Stem cell therapy demonstrates significant potential for regenerating dentin in TDIs. Future studies should explore long-term outcomes and optimization of protocols.
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