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The Brain-Face Connection in Holoprosencephaly: Case Report and Literature Review
Andreea Florentina Stancioi-Cismaru1,2,3, Florentina Gratiela Dita3,4, Razvan Cosmin Pana2,5
18th Department, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania.
Current Health Sciences Journal
|April 20, 2026
Summary
Holoprosencephaly (HPE) is a severe congenital brain malformation often diagnosed in early pregnancy. This study highlights that alobar HPE is frequently lethal, with rare survival beyond the neonatal period and significant impairment.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Genetics
Background:
- Holoprosencephaly (HPE) is a congenital brain malformation resulting from incomplete forebrain division.
- It presents a spectrum of severity, from alobar to lobar forms, often associated with midline craniofacial defects.
- Early first-trimester diagnosis is possible for HPE and associated anomalies.
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