Collagen depletion, not keloid formation, defines lobomycosis lesions: a paired skin analysis
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Updated: Apr 21, 2026

Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
Published on: August 21, 2021
Franciely G Gonçalves1,2, Juliana M Veridiano3, Nuha A Dsouki3
1Graduate Program in Health Sciences, FMABC University Center, Santo André, SP, 09060-650, Brazil.
Abstract:
Lobomycosis is a chronic cutaneous infection caused by the uncultivable fungus Paracoccidioides lobogeorgii. Lesions are often described as keloid-like, but the organization of the dermal extracellular matrix remains poorly characterized. We analyzed paired lesional and non-lesional skin from five patients in the Brazilian Amazon using histology and immunohistochemistry. Picrosirius red staining revealed depletion and disorganization of type I collagen in lesional dermis. Immunohistochemistry showed modest differences in biglycan and decorin expression, with spatial redistribution of biglycan near fungal structures. Patients treated with itraconazole showed lesion stabilization. These findings indicate collagen loss rather than true keloid formation.
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