Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

4
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
4
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

3.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
3.3K
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

17
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
17
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

3.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
3.7K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.4K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.4K
Diphtheria01:28

Diphtheria

156
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
156

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Procedure-related vasospasm and reperfusion vulnerability during mechanical thrombectomy.

Frontiers in neurology·2026
Same author

Risk Factors for Developing Critical Illness Polyneuropathy at a Referral Medical Center in Lebanon: A Prospective Cohort Study.

Cureus·2025
Same author

Oculopharyngeal Muscular Dystrophy Responding to Treatment: A Report of 2 Cases.

Journal of clinical neuromuscular disease·2025
Same author

Exploring gender disparity in medicine: perceptions of female physicians in Lebanon.

BMC medical education·2024
Same author

Petrous apicitis presenting with Horner's syndrome.

Acta neurologica Belgica·2021

Related Experiment Video

Updated: Apr 21, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

3.6K

Anti-GD1b Disorder Presenting as Multiple Mononeuropathies.

Kamar Eid1, Rim Araoui1, Ragheb Ismail1

  • 1Department of Neurology American University of Beirut Medical Center Beirut Lebanon.

Clinical Case Reports
|April 20, 2026
PubMed
Summary

Isolated anti-GD1b antibody disorders are rare, typically causing eye muscle paralysis and sensory ataxia. This case showed isolated mononeuropathies and responded dramatically to steroids, unlike typical immunosuppressive treatments.

Keywords:
antigangliosidesanti‐GD1bmononeuropathyopthalmoplegiasensory neuropathy

More Related Videos

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

10.2K
Preparation of CD4+ T Cells for Analysis of GD3 and GD2 Ganglioside Membrane Expression by Microscopy
10:00

Preparation of CD4+ T Cells for Analysis of GD3 and GD2 Ganglioside Membrane Expression by Microscopy

Published on: November 8, 2016

9.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

3.6K
A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
07:30

A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments

Published on: November 9, 2017

10.2K
Preparation of CD4+ T Cells for Analysis of GD3 and GD2 Ganglioside Membrane Expression by Microscopy
10:00

Preparation of CD4+ T Cells for Analysis of GD3 and GD2 Ganglioside Membrane Expression by Microscopy

Published on: November 8, 2016

9.1K

Area of Science:

  • Neurology
  • Immunology
  • Autoimmune Disorders

Background:

  • Isolated anti-GD1b antibody disorders are rare neurological conditions.
  • Typical presentations include ophthalmoplegia, sensory ataxia, paraproteinemia, and elevated cold agglutinins.
  • Response to immunosuppressive therapy is often limited.

Purpose of the Study:

  • To report a unique case of isolated mononeuropathies associated with anti-GD1b antibodies.
  • To highlight an atypical presentation without ataxia or paraproteinemia.
  • To investigate the treatment response in this rare condition.

Main Methods:

  • Case report of a patient with neurological symptoms.
  • Serological testing for anti-GD1b antibodies.
  • Clinical assessment of neurological deficits and treatment response.

Main Results:

  • The patient presented with isolated mononeuropathies, lacking typical ataxia and paraproteinemia.
  • Anti-GD1b antibodies were detected.
  • A short course of steroid treatment resulted in a dramatic clinical improvement.

Conclusions:

  • Isolated anti-GD1b antibody-associated mononeuropathies can occur without ataxia or paraproteinemia.
  • Steroid therapy may be highly effective in such cases.
  • This finding challenges the conventional understanding of anti-GD1b antibody disorder manifestations and treatment.