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Updated: Apr 21, 2026

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Persistent vessel wall enhancement and progression of cerebral microbleeds in CADASIL: a case report

Wenjuan Xu1, Chao Zhang2, Xiaomin Liu3

  • 1Department of General Practice, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.

Frontiers in Radiology
|April 20, 2026
PubMed

Insights

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) shows persistent vessel wall enhancement on MRI, suggesting blood-brain barrier disruption. This finding may help understand disease progression in hereditary cerebral small vessel disease.

Area of Science:

  • Neurology
  • Radiology
  • Genetics

Background:

  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a common hereditary cerebral small vessel disease (cSVD).
  • It is primarily caused by NOTCH3 gene mutations and characterized by progressive neuroimaging findings like white matter hyperintensities and microbleeds.
  • The underlying pathophysiology of neuroimaging progression in CADASIL is not fully understood.

Keywords:
case reportcerebral autosomal dominant arteriopathy with subcortical infarcts andleukoencephalopathycerebral microbleedsstrokevessel wall enhancement

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