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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
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Increased Body Temperature01:25

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Decreased Body Temperature01:29

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Increased Intracranial Pressure ll: Pathophysiology01:29

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Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
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A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury
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Temperature control in acute brain injury.

Andrea Lavinio1,2, Katharina M Busl3, Jonathan P Coles4,5

  • 1Perioperative, Acute, Critical Care and Emergency Medicine (PACE) Section, Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. andrea.lavinio1@nhs.net.

Intensive Care Medicine
|April 20, 2026
PubMed
Summary

Temperature management in neurocritical care has shifted from hypothermia to early fever detection and controlled normothermia. This approach protects the injured brain by preventing temperature-related harm.

Keywords:
Acute brain injuryFeverHypothermiaOutcomeTemperature

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Area of Science:

  • Neurocritical care
  • Temperature regulation
  • Cerebral physiology

Background:

  • Temperature significantly impacts brain vulnerability after acute injury.
  • Therapeutic temperature management has evolved from hypothermia to controlled normothermia.
  • Continuous monitoring and active control are feasible in intensive care units.

Purpose of the Study:

  • To review the physiological basis for temperature management in neurocritical care.
  • To examine clinical evidence supporting current temperature control strategies.
  • To discuss contemporary practices in neurocritical care temperature management.

Main Methods:

  • Synthesized evidence from randomized trials and observational studies.
  • Included international consensus recommendations for various brain injuries.
  • Reviewed current monitoring and implementation strategies.

Main Results:

  • Fever correlates with poorer neurological outcomes.
  • Hypothermia may reduce intracranial pressure but not improve outcomes in traumatic brain injury.
  • Current guidelines favor fever detection and normothermia over mandatory hypothermia in most neurocritical care settings.

Conclusions:

  • Temperature control is crucial for protecting injured brains.
  • Continuous monitoring and prompt fever management are key.
  • Preventing temperature-related harm is a fundamental aspect of neurocritical care.