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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
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All objects, neglecting air resistance, fall with the same acceleration towards the Earth's center due to the force exerted by the Earth's gravity. This experimentally determined fact is unexpected because we are so accustomed to the effects of air resistance and friction that we expect light objects to fall slower than heavier ones. People believed that a heavier object had a greater acceleration when falling until Galileo Galilei (1564–1642) proved otherwise. We now know this is...
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From the Editors.

Anne Wojtak1, Richard Lewanczuk2

  • 1Anne Wojtak, is a senior healthcare leader with more than 20 years of experience in the home and community care sector in Ontario. She is the co-lead for East Toronto Health Partners (Ontario Health Team), has a consulting practice focused on health system strategy and is adjunct faculty at the University of Toronto in Toronto, ON.

Healthcare Quarterly (Toronto, Ont.)
|April 20, 2026
PubMed
Summary
This summary is machine-generated.

Canada's healthcare systems face significant strain due to aging populations and increased chronic diseases. A shift towards prioritizing health, wellness, and person-centered care is essential for transformation.

Area of Science:

  • Health Services Research
  • Public Health Policy

Background:

  • Canadian healthcare systems, like global counterparts, are experiencing unprecedented strain.

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  • Key pressures include demographic shifts (aging population), rising chronic and mental health conditions, increased patient complexity, and workforce instability.
  • Current capacity is insufficient to meet escalating care demands.