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Related Experiment Video

Updated: Apr 22, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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Characterization of T-Cell Ubiquitination in Melanoma and Development of a Risk Signature Using Single-Cell and Bulk

Jianping Lu1, Cheng Lin2, Wei Gao3,4

  • 1Department of Pathology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, China.

Immunology
|April 21, 2026
PubMed
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This study identifies six ubiquitination-related genes (URGs) that predict cutaneous melanoma (CM) patient survival and influence the immune microenvironment, offering potential for new immunotherapies.

Area of Science:

  • Oncology
  • Immunology
  • Genetics

Background:

  • Cutaneous melanoma (CM) is an aggressive cancer requiring early intervention.
  • The prognostic significance and immune regulatory mechanisms of ubiquitination-related genes (URGs) in CM are not well understood.

Purpose of the Study:

  • To develop a prognostic signature based on URGs for CM.
  • To investigate the association between this URG signature and immune modulation in CM.

Main Methods:

  • Integrated single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data.
  • Identified prognostic URGs using univariate and multivariate Cox regression.
  • Validated a six-gene signature (UBE2L6, SPSB1, PSMB9, PSMB10, RNF213, ATXN3) and performed pathway and immune cell infiltration analyses.
Keywords:
T cellscutaneous melanomaimmune cell infiltrationprognostic genessingle‐cell sequencingubiquitination

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Last Updated: Apr 22, 2026

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Main Results:

  • A six-gene URG signature effectively stratified CM patients into high- and low-risk groups with distinct survival outcomes.
  • The low-risk group showed enrichment in immune-related pathways like 'cytokine-cytokine receptor interaction' and 'antigen processing and presentation'.
  • Significant differences in 12 immune cell types were observed between risk groups, with PSMB9 correlating positively with CD8+ T cell abundance.

Conclusions:

  • URGs play a crucial role in modulating the immune microenvironment in CM, impacting patient prognosis.
  • The established URG signature provides valuable prognostic information for CM.
  • These findings offer novel insights for developing targeted immunotherapeutic strategies for CM.