Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

1.0K
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

7.5K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the image quality and brain microstructural exploration of mean apparent propagator-MRI-a pilot study.

BMC medical imaging·2026
Same author

Time-dependent Diffusion MRI for Predicting Response to Induction Chemotherapy in Nasopharyngeal Carcinoma.

Radiology. Imaging cancer·2026
Same author

Accelerating Discovery of Ternary Chiral Materials via Large-Scale Random Crystal Structure Prediction.

Inorganic chemistry·2026
Same author

The predictive value of MR cytometry in histological differentiation of rectal cancer: an exploratory study.

European radiology·2026
Same author

The Performance of MR Cytometry Imaging in Differentiating High- and Low-Grade Bladder Cancer.

Journal of magnetic resonance imaging : JMRI·2026
Same author

Cross-Modality Alignment Perception and Multi-Head Self-Attention Mechanism for Vision-Language-Action of Humanoid Robot.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Apr 23, 2026

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

3.0K

Mean Apparent Propagator MRI: A Potential Imaging Biomarker of Brain Microstructural Alterations in Basic-Type

Qinglei Shi1,2, Mengdi Zhou3, Diwei Shi4

  • 1School of Medicine, Chinese University of Hong Kong (Shenzhen), Shenzhen, China.

Investigative Ophthalmology & Visual Science
|April 21, 2026
PubMed
Summary

Mean apparent propagator magnetic resonance imaging (MAP-MRI) reveals widespread brain changes in children with intermittent exotropia (IXT). These MAP-MRI metrics correlate with disease severity, offering potential biomarkers for IXT.

More Related Videos

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

10.1K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

19.8K

Related Experiment Videos

Last Updated: Apr 23, 2026

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping
09:55

Neuroimaging-Guided TMS–EEG for Real-Time Cortical Network Mapping

Published on: June 13, 2025

3.0K
A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy
08:23

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

10.1K
The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism
13:56

The Use of Magnetic Resonance Spectroscopy as a Tool for the Measurement of Bi-hemispheric Transcranial Electric Stimulation Effects on Primary Motor Cortex Metabolism

Published on: November 19, 2014

19.8K

Area of Science:

  • Neuroimaging
  • Ophthalmology
  • Pediatric Neurology

Background:

  • Intermittent exotropia (IXT) is a common childhood strabismus affecting binocular vision and oculomotor control.
  • Understanding the underlying brain alterations in IXT is crucial for developing effective diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate brain microstructural alterations in children with basic-type IXT using mean apparent propagator magnetic resonance imaging (MAP-MRI).
  • To analyze the correlations between MAP-MRI metrics and clinical signs of IXT.

Main Methods:

  • MRI scans (3T Siemens) including 3D T1-weighted and diffusion-weighted images were acquired from 78 children with basic-type IXT and 96 healthy controls.
  • MAP-MRI parametric maps were reconstructed, and voxel-wise analysis and fiber tractography were performed to assess microstructural changes in cortical regions and the visual pathway.
  • Receiver operating characteristic (ROC) analysis was used to evaluate the discriminative performance of MAP-MRI metrics.

Main Results:

  • MAP-MRI identified extensive microstructural alterations in brain regions related to binocular vision, oculomotor control, cognition, and emotion regulation in children with IXT (P < 0.01).
  • MAP-MRI metrics demonstrated excellent discriminative performance (AUC = 0.986) in differentiating IXT from controls.
  • Significant correlations were found between MAP-MRI metrics and IXT disease severity and duration (P < 0.05).

Conclusions:

  • MAP-MRI effectively detects widespread microstructural brain changes associated with IXT in children.
  • These findings provide insights into the neural underpinnings of impaired binocular vision and oculomotor control in IXT.
  • MAP-MRI metrics show potential as noninvasive imaging biomarkers for IXT-related microstructural alterations.