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Related Experiment Video

Updated: Jun 8, 2026

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BSxCuBE-Web - a web application for bioSAXS high-throughput collection and experimental control.

Jean Baptiste Florial1, Marcus Oscarsson2, Antonia Beteva2

  • 1European Molecular Biology Laboratory (EMBL), 71 avenue des Martyrs, CS 9018 38042, Grenoble, France.

Journal of Synchrotron Radiation
|April 21, 2026
PubMed
Summary

The BioSAXS Customized Beamline Environment (BSxCuBE-Web) platform enhances biological small-angle X-ray scattering (bioSAXS) data collection. This open-source tool streamlines experiments, improving efficiency and accessibility for researchers at the ESRF.

Keywords:
automationbiological small-angle X-ray scatteringexperimental controlweb technologies

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Area of Science:

  • Structural Biology
  • Biophysics
  • Synchrotron Radiation

Background:

  • The ESRF's BM29 biological small-angle X-ray scattering (bioSAXS) beamline was upgraded following the ESRF Extremely Brilliant Source (EBS) project.
  • Significant refurbishment of the BM29 beamline included source optimization, instrument upgrades, and a redesigned experimental control system.

Purpose of the Study:

  • To introduce the BioSAXS Customized Beamline Environment (BSxCuBE-Web), a novel open-source, web-based platform.
  • To streamline, automate, and enhance bioSAXS data collection for both expert and non-expert users.

Main Methods:

  • Development of BSxCuBE-Web, an open-source, web-based experimental control platform.
  • Implementation of an intuitive interface for experiment definition, execution, and data monitoring.
  • Validation of the platform using diverse biological samples at the BM29 beamline.

Main Results:

  • BSxCuBE-Web successfully supported over 97 experiments and 256 users at BM29 in 2025.
  • The platform demonstrated significant improvements in data collection efficiency, accessibility, and reliability.
  • User feedback highlighted a positive experience and validated the interface's effectiveness.

Conclusions:

  • BSxCuBE-Web provides a user-friendly and adaptable solution for bioSAXS data collection.
  • The platform's open-source nature and successful deployment facilitate its adoption at other beamlines.
  • Continuous development based on user feedback ensures BSxCuBE-Web meets evolving experimental needs in structural biology.