Biphasic Pulmonary Blastoma: A Rare Tumor With Fatal Outcome-First Reported Case From Lebanon

Biphasic pulmonary blastoma is a rare lung malignancy, accounting for less than 0.5% of all primary lung tumors. It is characterized by a biphasic nature of those tumors that consist of an admixture of epithelial and mesenchymal components. Up to this date, no standardized treatment approach has been developed and patient's prognosis remains poor. We present the case of an 85 year-old female who presented with dyspnea, associated with cough and hemoptysis, that has rapidly evolved over the past weeks, along with severe weight loss and anorexia. The patient was ultimately diagnosed with biphasic pulmonary blastoma on a liver core biopsy. To the best of our knowledge, this is the first case of biphasic pulmonary blastoma to be reported in Lebanon. The aggressive biological behavior of this rare tumor is highlighted by the occurrence of liver metastasis early on. It underlines the importance of recognizing this entity, even in metastatic sites. Death occurring within days of biopsy illustrates the fulminant course of those malignancies and its capacity to outpace routine diagnostic evaluation.