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Updated: Apr 23, 2026

Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer
Published on: February 13, 2019
The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases
Minghao Li1,2, Ruiyi Zhang3, Xinyuan Li4
1Obstetrics and Gynecology Hospital Institute of Reproduction and Development Fudan University Shanghai China.
Abstract:
The heart, as the central organ of the circulatory system, undergoes distinct metabolic transitions from embryonic development through postnatal maturation. A key aspect of this transition is mitochondrial maturation, which is influenced by changes in oxygen levels and metabolic substrates. These changes regulate cardiac structure and function by affecting signaling pathways and transcription factors. In cardiovascular diseases, mitochondria play a crucial role in altering metabolic patterns, contributing to pathological remodeling and worsening disease outcomes. This article explores mitochondrial roles in both cardiac development and disease progression, offering insights into potential therapeutic interventions.
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