Long-Term Reproducibility of OCT Angiography Parameters in Patients with High Myopia

To evaluate the long-term reproducibility of OCT angiography parameters in patients with high myopia.

A retrospective study.

Patients with high myopia and normal controls.

Subjects were divided into 2 groups: patients with high myopia (HM group) and normal controls (control group). Measurements of foveal avascular zone (FAZ) area, vessel density (VD) of superficial vascular complex (SVD), deep vascular complex (DVD), and choriocapillaris (CVD) were analyzed 3 times at 6-month intervals. Intraclass correlation coefficient (ICC) and coefficient of variation (CV) values were calculated.

Intraclass correlation coefficient and CV of SVD, DVD, and CVD.

A total of 194 eyes were enrolled: 99 in the HM group and 95 controls. In the HM group, the ICC/CV of FAZ area were 0.783/20.8%, versus 0.931/9.5% in controls. For SVD, values were 0.636/15.9% in HM group and 0.827/9.7% in controls; for DVD, 0.590/15.7% and 0.731/9.8%; for CVD, 0.672/9.8% and 0.842/7.2%, respectively. In linear regression analysis, image quality was associated with the CV of SVD (B = -1.38, P = 0.004) and DVD (B = -1.86, P = 0.004). For CVD, multivariable analysis showed that axial length (B = 1.93, P < 0.001) and image quality (B = -1.13, P = 0.004) were significantly associated with the CV.

Reproducibility of the FAZ area was relatively good, while SVD and CVD were moderate, and DVD was the poorest in high myopia. OCT angiography image quality had a significant impact on the long-term reproducibility of VD in all layers.

The authors have no proprietary or commercial interest in any materials discussed in this article.