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Covalently Linked Protein Regulators

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Related Experiment Video

Updated: Apr 23, 2026

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Characterizing RNA Modifications in Single Neurons Using Mass Spectrometry

Published on: April 21, 2022

RNA Modifications: Current Understandings and Future Perspectives.

Shiyu Xiao¹, Tingwen Xiang¹, Chuan Yang^1,2

¹Department of Orthopedics, Southwest Hospital Third Military Medical University (Army Medical University) Chongqing People's Republic of China.

|April 22, 2026

Summary

This summary is machine-generated.

RNA modifications, like N4-acetylcytidine (ac4C), regulate gene expression. Enzymes such as N-acetyltransferase 10 (NAT10) are key targets for understanding and treating diseases.

Keywords:

N4‐acetylcytidine RNA modification epigenetic modification homeostasis pathophysiology

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Area of Science:

Epitranscriptomics
Molecular Biology
Gene Regulation

Background:

RNA modifications are crucial for gene expression control.
N6-methyladenosine (m6A) is the most common RNA modification.
Other modifications, including N4-acetylcytidine (ac4C), also play vital regulatory roles.

Purpose of the Study:

To systematically review RNA modification research using ac4C as a paradigm.
To explore the discovery, mechanisms, detection, and significance of ac4C.
To elucidate the roles of RNA modifications and related enzymes in health and disease.

Main Methods:

Systematic review of RNA modification literature.
Focus on ac4C modification and its regulatory enzyme, NAT10.
Analysis of ac4C's functional significance in physiological and pathological conditions.

Main Results:

RNA modifications are dynamic regulators of RNA metabolism, transport, and translation.
NAT10 is a key enzyme involved in ac4C modification.
ac4C plays significant roles in both normal cellular functions and disease states.

Conclusions:

RNA modifications, exemplified by ac4C, have multidimensional roles in health and disease.
Enzymes like NAT10 are potential prognostic biomarkers and therapeutic targets.
Further research can advance disease mechanism understanding and clinical applications.