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Updated: Apr 23, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Amphiphilic poly(aminoester) dendrimers: click reaction-enabled synthesis, structure-governed self-assembly and
Yonghui Ma1, Junyue Zheng1, Dandan Zhu1
1State Key Laboratory of Natural Medicines, Joint International Research Laboratory of Target Discovery and New Drug Innovation (Ministry of Education), Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing 210009, P. R. China. xiaoxuanliu@cpu.edu.cn.
None:
Poly(aminoester) (PAE) dendrimers are attractive materials for biomedical applications owing to their biodegradability and precise structure, effective synthesis and favourable safety profile. We report here a click chemistry-enabled divergent-convergent strategy for the efficient synthesis of amphiphilic PAE dendrimers. These dendrimers exhibit negligible cytotoxicity, generation-dependent degradation behaviour, and tunable self-assembly controlled by the hydrophobic chain length. This study offers an accessible synthesis of PAE dendrimers, advancing their use in future biomedical applications.
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