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Integrin Beta 4 Protein Expression Bimodally Predicts Sensitivity to CDK4/6 Inhibition and Resistance to

Zhi-Min Zhu1, Lei Hu2, Yan-Wen Ma3

  • 1Department of Pharmaceutics, Shanghai Eighth People's Hospital, Shanghai, China, sh8y.com.

The Breast Journal
|April 22, 2026
PubMed
Summary

Integrin beta 4 (ITGB4) protein levels, not RNA, predict breast cancer outcomes. High ITGB4 indicates better prognosis and CDK4/6 inhibitor sensitivity in ER-positive cases, but immunotherapy resistance in triple-negative breast cancer.

Keywords:
CDK4/6 inhibitorITGB4biomarkerbreast cancerimmunotherapy resistancemultiomics

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