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    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Computer Science

    Background:

    • Brain-computer interfaces (BCIs) are crucial for assistive technologies, but limited command sets and high calibration costs hinder practical use.
    • Existing BCIs struggle to balance command quantity with user-friendly calibration procedures.

    Purpose of the Study:

    • To develop a functional optimization-based encoding framework for generating a large number of highly discriminable commands with reduced calibration.
    • To enhance BCI control capacity and efficiency for real-world applications.

    Main Methods:

    • Implemented a functional optimization theory to improve command distinguishability by optimizing encoding functions.
    • Utilized a few-shot training strategy and symbol reusability to minimize calibration data requirements.
    • Employed a symbol-joint decoding approach to boost recognition accuracy.

    Main Results:

    • Developed an online BCI system with 1,008 commands, achieving state-of-the-art in command scale and calibration efficiency.
    • Demonstrated a 13.94% increase in accuracy and a 26.12% increase in information transfer rate (ITR) compared to baseline methods.
    • Achieved high accuracy (86.60%) and ITR (122.74 bits/min) with only 72 seconds of calibration across 15 subjects.

    Conclusions:

    • The functional optimization framework significantly enhances BCI performance, offering unprecedented command scale and calibration efficiency.
    • The system's flexibility and compatibility across paradigms suggest broad applicability and improved practicality for large-scale BCIs.
    • This approach overcomes key limitations in current BCIs, paving the way for more sophisticated and accessible brain-computer interfaces.