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VV116 exerts potent efficacy against feline infectious peritonitis
Huilong Wang1, Haoli Yi2, Wei Zheng3
1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
Feline infectious peritonitis (FIP) is a fatal disease in cats caused by feline infectious peritonitis virus (FIPV) with no officially approved antiviral therapy. In this study, we evaluated the anti-FIPV potential of VV116 and found that it potently inhibited viral replication in CRFK cells (EC50 = 1.57 μM). In experimental FIPV-infected cats, VV116 significantly reversed clinicopathological abnormalities, improved survival to 75%, and reduced viral loads in most organs to levels below or at the limit of detection, achieving a greater reduction compared to GS‑441524. Marked histopathological improvement was also observed in both treated groups. Together, these findings support VV116 as a promising oral candidate for the treatment of FIP and warrant further evaluation in veterinary clinical settings.
