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Investigating the effectiveness of ibuprofen mucoadhesive gel on minor recurrent aphthous stomatitis: a randomized
Tahereh Molania1, Majid Saeedi2, Anahita Lotfizadeh3
1Department of Oral Medicine, Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran; Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Objective:
Recurrent aphthous stomatitis (RAS) is the most common form of oral mucosal lesions. This preliminary study investigated the effectiveness of ibuprofen mucoadhesive gel on minor aphthous lesions.
Study Design:
In this randomized double-blind clinical trial, 44 participants, 22 in each intervention and control groups, used mucoadhesive gels 6 times a day. On days 0 (baseline), 3, 5, and 7, the lesion diameter was measured. Pain intensity was recorded using a visual numerical scale (VNS). Independent t-test, Friedman, generalized estimating equation (GEE), Mann-Whitney, and Chi-square tests were used to analyze data. Data analysis was performed using SPSS 22.
Results:
Comparison of the difference in mean lesion diameter between the 2 groups on measurement days and the baseline showed significant results (P < .05). The reduction in lesion diameter was greater in the intervention group. The mean pain intensity of the intervention group on days 4 (1.31 ± 2.56), 5 (0.91 ± 1.00), and 6 (0.69 ± 0.39) was significantly lower than that of the control group on days 4 (3.91 ± 2.36), 5 (2.61 ± 2.36), and 6 (1.52 ± 1.60) (P < .05).
Conclusion:
The ibuprofen mucoadhesive gel resulted in a greater reduction in lesion diameter when comparing the results with the baseline and compared to the control group. Its analgesic effect was confined to days 4 to 6 of the study.
Clinical Trial Registration Number:
Iranian Registry of Clinical Trials (IRCT20241208063987N1).
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