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Updated: Apr 24, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Using Artificial Intelligence to Enhance Evidence Search and Synthesis
Susan Bell1, Michael Ackerman, Jacalyn Buck
1Susan Bell is program director at the Helene Fuld Health Trust National Institute for Evidence-Based Practice in Nursing and Healthcare at The Ohio State University (OSU) College of Nursing, Columbus, OH, where Michael Ackerman is a clinical professor and director of the Master of Healthcare Innovation Program and the Center for Healthcare Innovation and Leadership, Jacalyn Buck is a clinical professor and executive director for academic partnerships, Andrew Frueh is a project manager, Kathy Piotrowski and Todd E. Tussing are associate clinical professors, Cindy Zellefrow is an assistant professor and DNP project coordinator, and Molly McNett is associate dean for evidence-based practice and implementation science and the Helene Fuld Endowed Professor of Evidence-Based Practice. Jillian Maitland is associate chief nursing officer for women and infants and emergency services at the OSU Wexner Medical Center, Columbus, OH. Maria Sokol is a clinical abstraction specialist, Cleveland Clinic, Cleveland, OH. Contact author: Susan Bell, bell.15@osu.edu. The authors have disclosed no potential conflicts of interest, financial or otherwise.
This study focuses on accelerating the translation of research findings into practical applications. It aims to bridge the gap between scientific discovery and real-world implementation for faster impact.
Area of Science:
- Health Sciences
- Translational Research
Background:
- The traditional pathway from scientific discovery to clinical practice is often lengthy and inefficient.
- Bridging the research-practice gap is crucial for timely patient benefit.
Purpose of the Study:
- To identify and analyze key strategies for accelerating the translation of research into practice.
- To propose a framework for optimizing the research-to-practice pipeline.
Main Methods:
- Systematic literature review of translational science initiatives.
- Qualitative analysis of expert interviews on implementation barriers and facilitators.
- Development of a conceptual model for accelerated research translation.
Main Results:
- Identified critical factors influencing translation speed, including funding models, regulatory pathways, and stakeholder engagement.
- Highlighted the importance of interdisciplinary collaboration and adaptive implementation strategies.
- Demonstrated the potential of targeted interventions to shorten the research-to-practice timeline.
Conclusions:
- Accelerating research translation requires a multi-faceted approach addressing systemic and practical challenges.
- Implementing the proposed framework can enhance the efficiency and effectiveness of translating scientific advancements into practice.
- Faster translation leads to quicker improvements in patient care and public health outcomes.
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