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Updated: Apr 24, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
An autopsy case of malignant pleural mesothelioma presenting with an elevated G-CSF level and neutrophil-predominant
Yukine Senda1, Seisuke Okazawa2, Daisuke Furukawa2
1Clinical Training Center, Toyama University Hospital, Japan.
Abstract:
A 77-year-old man was admitted with respiratory failure. Chest computed tomography revealed right pleural thickening and pleural effusion. A cytological examination of the pleural fluid showed a predominance of neutrophils without any malignant findings. The peripheral white blood cell count increased to a maximum of 74,070/μL. Laboratory tests revealed that the serum level of granulocyte colony-stimulating factor (G-CSF) was 268 pg/mL. The autopsy findings indicated malignant pleural mesothelioma. The clinical course was consistent with that of G-CSF-producing malignant pleural mesothelioma. This is a rare case of desmoplastic malignant pleural mesothelioma that clinically mimicked a G-CSF-producing tumor and empyema.
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