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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photocatalytic Regioselective Four-Component 1,4-Aryl Migration of N-Allylbenzamides To Access β-Arylethylamines
Cong-Hui Zhan1, Hao Xu1, Yi Li1
1State Key Laboratory of Advanced Optical Polymer and Manufacturing Technology, Qingdao Key Laboratory of Biomacromolecular Drug Discovery and Development, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.
Abstract:
Radical-mediated rearrangement reactions serve as a powerful strategy for the construction of novel molecular frameworks. Herein, we report a photochemical four-component 1,4-aryl migration protocol for the highly regioselective synthesis of functionalized β-(hetero)arylethylamines. This practical approach employs readily accessible N-allylbenzamides and aryl thianthrenium salts, along with commercially available alcohols and (DABCO)·(SO2)2 (DABSO) as starting materials, and proceeds smoothly under mild reaction conditions. Moreover, this method tolerates a wide range of migratory aryl groups bearing diverse substitution patterns and electronic properties.
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