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Ultrasound-Guided Injectable Adhesive Hydrogel Enabling Targeted Hemostasis in Deep and Incompressible Wounds.

Yadong Liu1, Han Yang1,2, Zihan Mei3

  • 1School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.

Advanced Healthcare Materials
|April 23, 2026
PubMed
Summary
This summary is machine-generated.

A new injectable hydrogel (OPH) offers rapid ultrasound-guided hemostasis for deep wounds. This bio-based material effectively controls bleeding and exhibits antibacterial properties, outperforming traditional hemostats.

Keywords:
adhesivehemostasisin situinjectableultrasound‐guided therapy

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Conventional hemostats are inadequate for deep, incompressible visceral wounds, particularly without surgical access.
  • There is a critical need for advanced hemostatic agents that are injectable and can be precisely delivered.
  • Existing materials often fail to provide rapid and effective bleeding control in challenging anatomical locations.

Purpose of the Study:

  • To design and develop an injectable, bio-based hydrogel for ultrasound-guided hemostasis.
  • To evaluate the hemostatic efficacy, adhesion strength, and antibacterial properties of the novel hydrogel.
  • To compare the performance of the new hydrogel against commercially available hemostatic agents.

Main Methods:

  • Chemically modified natural polymers (hyaluronic acid, chitosan, polylysine) were cross-linked via Schiff base reaction at room temperature.
  • A dual-syringe system was employed for instant hydrogel formation and injection.
  • Hemostatic performance was assessed in intestinal wounds and rabbit liver injury models, with ultrasound guidance.
  • Adhesion strength and bursting pressure were quantified; antibacterial activity was tested against Staphylococcus aureus and Escherichia coli.

Main Results:

  • The optimized hydrogel (OPH) demonstrated a wet adhesion strength of ~45 kPa and withstood a bursting pressure of 123 mmHg in intestinal wounds.
  • OPH exhibited significant antibacterial activity against Staphylococcus aureus and Escherichia coli due to its cationic components.
  • In rabbit models, ultrasound-guided in situ injection of OPH effectively sealed liver injuries and controlled bleeding, reducing complications.
  • OPH matched the coagulation performance of commercial hemostats while showing superior suitability for deep wounds.

Conclusions:

  • The developed OPH hydrogel represents a high-performance hemostatic platform for challenging bleeding scenarios.
  • Its synergistic design, featuring rapid covalent cross-linking, inherent cationic activity, and ultrasound-guided delivery, offers significant advantages.
  • This injectable hydrogel shows promise as a next-generation trauma-care material, particularly for deep and inaccessible wounds.