Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

553
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
553
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

1.4K
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
1.4K
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

1.6K
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
1.6K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

522
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
522
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

778
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
778
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

2.2K
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

New strategy to regulate immunopathogenic processes of glomerulonephritis.

Kidney research and clinical practice·2026
Same author

Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection.

bioRxiv : the preprint server for biology·2026
Same author

The evolving landscape of acute kidney injury: research directions and changes in clinical practice.

Kidney research and clinical practice·2026
Same author

Reversing pregnancy-induced B cell sensitization to facilitate the induction of transplant tolerance in postpartum recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

Genetic Landscape of Kidney Failure in a Korean Transplant Cohort: Genome-Wide Association and Multi-Polygenic Risk Score Analyses.

Journal of the American Society of Nephrology : JASN·2026
Same author

Programmable 3D Photovoltaics via Mechanically Origami-Coded Interlocked 3D Kirigami and Nano-Root Anchored AgNWs-In-Ga Multiphasic Alloy Conductor.

Advanced materials (Deerfield Beach, Fla.)·2026

Related Experiment Video

Updated: Apr 24, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.3K

Shifts in Acute Kidney Injury Trends Post-Alert System Implementation: A Retrospective Observational Cohort Study.

Jinyeong Yi1, Jiwon Ryu2,3, Tran Tuan Tu4,5

  • 1Center for Artificial Intelligence in Healthcare, Seoul National University Bundang Hospital, Republic of Korea.

Kidney Medicine
|April 23, 2026
PubMed
Summary

An automated acute kidney injury (AKI) alert system significantly improved patient recovery rates and early nephrology consultations over ten years. The system demonstrated sustained effectiveness in managing AKI, reducing overlooked cases and long-term kidney function decline.

Keywords:
Acute kidney injury (AKI)Alert Systemelectronic health records (EHRs)nephrotoxic medicationstime series analysis

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.1K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.2K

Related Experiment Videos

Last Updated: Apr 24, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.3K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.1K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

3.2K

Area of Science:

  • Nephrology
  • Clinical Informatics
  • Healthcare Management

Background:

  • Acute kidney injury (AKI) is a critical condition requiring prompt intervention.
  • The long-term impact of AKI alert systems on patient outcomes and clinical practice remains under-evaluated.
  • This study assesses the sustained effectiveness of an AKI alert system over a decade.

Purpose of the Study:

  • To investigate the long-term effectiveness of an automated AKI alert system.
  • To evaluate the sustained impact on AKI recovery, progression, and mortality.
  • To assess improvements in clinical processes like nephrology consultation and AKI monitoring.

Main Methods:

  • Retrospective observational cohort study of 13,301 adult AKI patients over ten years (2013-2023) at a tertiary hospital.
  • Comparison of outcomes across pre-alert, alert implementation, and pandemic phases using multivariable logistic and interrupted time series analyses.
  • Primary outcomes: AKI recovery, stage progression, dialysis, mortality. Process outcomes: early nephrology consultation, overlooked AKI, nephrotoxic medication use. Long-term outcome: eGFR decline.

Main Results:

  • Sustained significant increases in AKI recovery rates (adjusted OR 2.40-2.19) and early nephrology consultations (adjusted OR 3.33-2.65) were observed.
  • A significant decrease in overlooked AKI cases (adjusted OR 0.49-0.43) and a lower risk of long-term eGFR decline (adjusted OR 0.86) were noted.
  • Interrupted time series analysis confirmed immediate improvements in key outcomes post-implementation.

Conclusions:

  • The AKI alert system demonstrated sustained positive effects on AKI management over a decade.
  • The system effectively improved AKI recovery, facilitated early nephrology consultation, and enhanced monitoring.
  • The findings support the long-term value of automated AKI alert systems in diverse healthcare settings.