[THE DIGITAL PHENOTYPING OF AGING WITH APPLICATION OF HEMODYNAMIC PARAMETERS]

The article presents materials of the original study on digital phenotyping of aging using expanded range of systemic hemodynamic parameters by establishing correlation with trends of biological age. The increasing of biological age with respect to actual age was considered as sign of accelerated aging. The opposite ratio was considered as manifestation of slowed aging. The relationship of accelerated aging with increasing of such key hemodynamic indicators as systolic, pulse and mean arterial pressure is confirmed. The data regarding relatively high diagnostic value of lateral arterial pressure as marker of accelerated aging were obtained. The obtained data permit to suppose that risk of accelerated aging is associated not only with high values of cardiac index but also with low ones, forming U-shaped dependence. The direct relationship between accelerated aging and decreasing of efficiency of heart functioning was established. Also inverse relationship between rate of biological aging and functional reserve of myocardium were detected. It is established that accelerated aging is associated with significant decreasing of heart energy capacity. The absolute correlation between accelerated aging and increased total peripheral vascular resistance was fixed. on the contrary, decreased value of this indicator was observed during slowed aging. The established regularities can be applied to monitor and to adjust optimal regimen of functioning.