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Related Experiment Video

Updated: Jun 18, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neurodevelopment after a strength-based intervention in children born extremely preterm: a randomised controlled

Anna Hallin Provenzano^1,2, Noni Wadström^3,4, Kristina Löwing^3,5

¹Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. anna.hallin.provenzano@ki.se.

Pediatric Research

|April 23, 2026

Summary

The Stockholm Preterm Interaction-Based Intervention did not show short-term neurodevelopmental benefits for extremely preterm infants at 24 months corrected age. Further research is needed to explore long-term effects and optimize early support programs.

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Published on: February 2, 2024

Area of Science:

Neonatal care and development
Pediatric neurodevelopmental research
Intervention studies in preterm infants

Background:

Extremely preterm birth poses significant risks for neurodevelopmental impairments.
Early parent-infant interventions may support development, but evidence remains limited.
The Stockholm Preterm Interaction-Based Intervention was evaluated for its impact on neurodevelopment.

Purpose of the Study:

To assess the effect of the Stockholm Preterm Interaction-Based Intervention on neurodevelopmental outcomes at 24 months corrected age.
To examine the risk of autism spectrum disorder as a separate outcome.
To investigate if intervention effects varied based on biological and psychosocial factors.

Main Methods:

A randomized controlled trial involving 130 extremely preterm infants.
Participants were assigned to either an intervention group (intervention + extended follow-up) or a control group (extended follow-up only).
Neurodevelopment was assessed using the Bayley Scales of Infant and Toddler Development, 3rd edition, at 24 months corrected age.

Main Results:

No significant differences in cognitive, language, or motor development were observed between groups.
This lack of difference was consistent in the overall cohort and in subgroups, including those at risk for autism spectrum disorder.
No interaction effects were found concerning biological and psychosocial factors.

Conclusions:

The intervention did not demonstrate short-term neurodevelopmental benefits at 24 months corrected age in this cohort.
Long-term follow-up is crucial to evaluate potential delayed effects of the intervention.
Findings highlight the need for continued evaluation and potential refinement of early support programs for preterm infants.